Lei et al.: "SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2"; show that Spike protein 'alone' can damage vascular endothelial cells (ECs) by downregulating ACE2
by Paul Alexander
COVID-19 is & was a vascular (blood clot) disease (as much as respiratory) & the SARS-CoV-2 virus (spike protein) attacks vascular system on a cellular level (spike protein from vaccine OR infection)
SOURCE:
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902
‘administered a pseudo-virus expressing S protein (Pseu-Spike) to Syrian hamsters intratracheally. Lung damage was apparent in animals receiving Pseu-Spike, revealed by thickening of the alveolar septa and increased infiltration of mononuclear cells’.
‘In the damaged lungs, levels of pAMPK (phospho-AMPK), pACE2 (phospho-ACE2), and ACE2 decreased but those of MDM2 increased’.
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