Publishing Record

  1. McCullough P, Alexander, PE et al.
    Multifaceted highly targeted sequential multidrug treatment of early ambulatory high-risk SARS-CoV-2 infection (COVID-19). Rev. Cardiovasc. Med. 2020 vol. 21(4), 517–530 ©2020 McCullough et al. Published by IMR Press.
  2. Alexander PA, Amstrong R, Fareed G et al.
    Early Multidrug Treatment of SARS-CoV-2 Infection (COVID-19) and Reduced Mortality Among Nursing Home Residents. Medical Hypotheses, online, June 5th2021, 110622; doi https://doi.org/10.1016/j.mehy.2021.110622
  3. Zeng L, Brignardello-Petersen R, Hultcrantz M, Siemieniuk RAC, Santesso N, Traversy G, Izcovich A, Sadeghirad B, Alexander PE, Devji T, Rochwerg B, Murad MH, Morgan R, Christensen R, Schünemann HJ, Guyatt GH.
    GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratings. J Clin Epidemiol. 2021 Apr 12:S0895-4356(21)00108-6. doi: 10.1016/j.jclinepi.2021.03.026. Epub ahead of print. PMID: 33857619.
  4. Mammen MJ, Aryal K, Alhazzani W, Alexander PE.
    Corticosteroids for patients with acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials. Pol Arch Intern Med. 2020 Mar 18. doi: 10.20452/pamw.15239. [Epub ahead of print] PubMed PMID: 32186831.
  5. Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A.
    Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19). Intensive Care Med. 2020 Mar 28. doi: 10.1007/s00134-020-06022-5.
  6. Paul E Alexander, Michael R. Gionfriddo, Shelly-Anne Li, Lisa Bero, Rebecca J Stoltzfus, Ignacio Neumann, Juan P. Brito, Benjamin Djulbegovic, Victor M. Montori, Susan L. Norris, Holger J Schünemann, Lehana Thabane, Gordon H Guyatt.
    A number of factors explain why WHO guideline developers make strong recommendations inconsistent with GRADE guidance. J Clin Epidemiol.2016 Feb;70:111-22. doi: 10.1016/j.jclinepi.2015.09.006. Epub 2015 Sep 21.
  7. Brignardello-Petersen R, Bonner A, Alexander PE, Siemieniuk RA, Furukawa TA, Rochwerg B, Hazlewood GS, Alhazzani W, Mustafa RA, Murad MH, Puhan MA, Schünemann HJ, Guyatt GH; GRADE Working Group.
    Advances in the GRADE approach to rate the certainty in estimates from a network meta-analysis. J Clin Epidemiol.2018 Jan;93:36-44. doi: 10.1016/j.jclinepi.2017.10.005. Epub 2017 Oct 17.
  8. Nici L, Mammen MJ, Charbek E, Alexander PE, Au DH, Boyd CM, Criner GJ, Donaldson GC, Dreher M, Fan VS, Gershon AS, Han MK, Krishnan JA, Martinez FJ, Meek PM, Morgan M, Polkey MI, Puhan MA, Sadatsafavi M, Sin DD, Washko GR, Wedzicha JA, Aaron SD; American Thoracic Society
    Assembly on Clinical Problems. Pharmacologic Management of COPD: An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020 Apr 13. doi:10.1164/rccm.202003-0625ST.

  9. Mammen MJ, Aryal K, Alhazzani W, Deng DY, Alexander PE.
    Interferon-β-1a for patients with moderate to severe acute respiratory distress syndrome: a systematic review and meta-analysis of randomized trials. Pol Arch Intern Med. 2020 Apr 3. doi: 10.20452/pamw.15279.
  10. Chatree Chai-Adisaksopha, Paul E. Alexander, Gordon Guyatt, Mark A. Crowther, Nancy M. Heddle, Martin Ellis, David Roxby, Daniel I. Sessler, John W. Eikelboom.
    Mortality outcomes in patients transfused with fresher versus older red blood cells: A meta-analysis. Vox Sang.2017;112 (3):268-278. doi: 10.1111/vox.12495. Epub 2017 Feb 20.
  11. Dipayan Chaudhuri, Alexander PEet al.
    Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis. Intensive Care Medicine (ICM). In-press, March 2021.

  12. Agoritsas T, Merglen A, Heen AF, Kristiansen A, Neumann I, Brito JP, Brignardello-Petersen R, Alexander PE, Rind DM, Vandvik PO, Guyatt GH.
    UpToDate adherence to GRADE criteria for strong recommendations: an analytical survey. BMJ Open.2017 Nov 16;7(11):e018593. doi: 10.1136/bmjopen-2017-018593.
  13. Mammen MJ, Alexander PE et al.
    Dual LABA/LAMA Therapy versus LABA or LAMA Monotherapy for COPD: A Systematic Review and Meta-analysis in Support of the American Thoracic Society Guideline. Annals of the American Thoracic Society, 2020, In-Press.
  14. Li SA, Alexander PE, Reljic T, Cuker A, Nieuwlaat R, Wiercioch W, Guyatt G, Schünemann HJ, Djulbegovic B.
    Evidence to Decision (EtD) framework provides a structured ‘roadmap’ for making GRADE guidelines recommendations. J ClinEpidemiol. 2018 Sep 22. pii: S0895-4356(17)31403-8. doi: 10.1016/j.jclinepi.2018.09.007.
  15. Alexander PE, Li SA, Gionfriddo MR, Bero L, Stoltzfus RJ, Neumann I, Brito JP, Djulbegovic B, Montori VM, Schünemann HJ, Guyatt GH.
    Experiences of senior GRADE methodologists as part of WHO guideline development panels: an inductive content analysis. J Clin Epidemiol.2015 Sep 15. pii: S0895-4356(15)00422-9.
  16. Uyeki TM, Bernstein HH, Bradley JS, Englund JA, File TM, Fry AM, Gravenstein S, Hayden FG, Harper SA, Hirshon JM, Ison MG, Johnston BL, Knight SL, McGeer A, Riley LE, Wolfe CR, Alexander PE, Pavia AT.
    Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza. Clin Infect Dis. 2019 Mar 5;68(6):e1-e47. doi: 10.1093/cid/ciy866. Erratum in: Clin Infect Dis. 2019 May 2;68(10):1790.

  17. Shawwa K, Kallas R, Koujanian S, Agarwal A, Neumann I, Alexander P, Tikkinen KA, Guyatt G, Akl EA.
    Requirements of clinical journals for authors’ disclosure of financial and non-financial conflicts of interest: a cross sectional study. PLOS ONE. 2016;11(3):e0152301. doi: 10.1371/journal.pone.0152301. eCollection 2016.
  18. Zhang Y, Tikkinen KA, Agoritsas T, Ayeni OR, Alexander P, Imam M, Yoo D, Tsalatsanis A, Djulbegovic B, Thabane L, Schünemann H, Guyatt GH.
    Patients’ values and preferences of the expected efficacy of hip arthroscopy for osteoarthritis: a protocol for a multinational structured interview-based study combined with a randomised survey on the optimal amount of information to elicit preferences. BMJ Open.2014;4(10):e005536.
  19. Alexander PE, Li SA, Tonelli M, Guyatt G.
    Canadian Primary Care Physicians’ Attitudes Toward Understanding Clinical Practice Guidelines for Diabetes Screening. Can J Diabetes.2016;40(6):580-585. doi: 10.1016/j.jcjd.2016.05.018. Epub 2016 Aug 30.
  20. Velandia Oscar M M, Alexander PE et al.
    Patients values and preferences regarding continuous subcutaneous insulin infusion (CSII) and artificial pancreas in adults with type 1 diabetes: a systematic review of quantitative and qualitative data. Diabetes Technology and Therapeutics. 2019 Mar 6. doi: 10.1089/dia.2018.0346. [Epub ahead of print].
  21. Alexander P, Heels-Ansdell D, Siemieniuk R, Bhatnagar N, Chang Y, Fei Y, Zhang Y, McLeod S, Prasad K, Guyatt G.
    Hemicraniectomy versus medical treatment with large MCA infarct: a review and meta-analysis. BMJ Open.2016;6(11):e014390. doi: 10.1136/bmjopen-2016-014390.

  22. Bonner A, Alexander PE, Brignardello-Petersen R, Furukawa TA, Siemieniuk RA, Zhang Y, Wiercioch W, Florez ID, Fei Y, Agarwal A, Yepes-Nuñez JJ, Beyene J, Schünemann H, Guyatt GH.
    Applying GRADE to a network meta analysis of antidepressants led to more conservative conclusions. JClinEpidemiol.2018 May 22. pii: S0895-4356(17)31085-5. doi: 10.1016/j.jclinepi.2018.05.009. [Epub ahead of print].
  23. Zhang Y, Flórez ID, Colunga Lozano LE, Bakar Aloweni FA, Kennedy SA, Li A, Craigie S, Zhang S, Agarwal A, Lopes LC, Devji T, Wiercioch W, Riva JJ, Wang M, Jin X, Fei Y, Alexander P, Morgano GP, Zhang Y, Carrasco-Labra A, Kahale LA, Akl EA, Schünemann HJ, Thabane L, Guyatt G.
    Reporting and methods for handling missing participant data for continuous outcomes in randomized controlled trials: a systematic survey. J Clin Epidemiol.2017 Jun 2. pii: S0895-4356(17)30573-5. doi: 10.1016/j.jclinepi.2017.05.017. [Epub ahead of print].
  24. Kahale LA, Diab B, Brignardello-Petersen R, Agarwal A, Mustafa RA, Kwong J, Neumann I, Li L, Lopes LC, Briel M, Busse JW, Iorio A, Vandvik PO, Alexander PE, Guyatt G, Akl EA.
    Systematic reviews do not adequately report, or address missing outcome data in their analyses: a methodological survey. J Clin Epidemiol.2018 Mar 2. pii: S0895-4356(17)31397-5. doi: 10.1016/j.jclinepi.2018.02.016.
  25. Siemieniuk RA, Foroutan F, Mirza R, Mah Ming J, Alexander PE, Agarwal A, Lesi O, Merglen A, Chang Y, Zhang Y, Mir H, Hepworth E, Lee Y, Zeraatkar D, Guyatt GH.
    Antiretroviral therapy for pregnant women living with HIV or hepatitis B: a systematic review and meta-analysis. BMJ Open.2017 Sep 11;7(9):e019022. doi: 10.1136/bmjopen-2017-019022.
  26. Paul E Alexander, Rebecca Barty, Yutong Fei, Per Olav Vandvik, Menaka Pai, Reed A.C. Siemieniuk,Nancy M Heddle,Neil Blumberg, Shelley L. McLeod, Jianping Liu, John W. Eikelboom, Gordon H Guyatt.
    Transfusion of fresher versus older red blood cells in hospitalized patients: a systematic review and meta-analysis. Blood. 2016 ;127(4):400-10. doi: 10.1182/blood-2015-09-670950. Epub 2015 Dec 1.

  27. Alexander PE, Bero L, Montori VM, Brito JP, Stoltzfus R, Djulbegovic B, Neumann I, Rave S, Guyatt G.
    World Health Organization recommendations are often strong based on low confidence in effect estimates. J Clin Epidemiol.2014;67(6):629-634. doi: 10.1016/j.jclinepi.2013.09.020. Epub 2014 Jan 3.
  28. Siemieniuk RA, Meade MO, Alonso-Coello P, Briel M, Evaniew N, Prasad M, Alexander PE, Fei Y, Vandvik PO, Loeb M, Guyatt GH.
    Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Ann Intern Med.2015;163(7):519-28. doi: 10.7326/M15-0715.
  29. Bonner A, Alexander P et al.
    Application of the GRADE approach added value to the interpretation of the results of a network meta-analysis of antidepressants. J Clin Epidemiol.In Press, 2018.
  30. Neumann I, Santesso N, Akl EA, Rind DM, Vandvik PO, Alonso-Coello P, Agoritsas T, Mustafa R, Alexander PE, Schunemann H, Guyatt GH.
    A guide for health professionals to interpret and use recommendations in guidelines developed with the GRADEapproach. J Clin Epidemiol. 2016; 72:45-55. doi: 10.1016/j.jclinepi.2015.11.017. Epub 2016 Jan 6. Review.
  31. Violette PD, Agoritsas T, Alexander P, Riikonen J, Santti H, Agarwal A, Bhatnagar N, Dahm P, Montori V, Guyatt GH, Tikkinen KA.
    Decision aids for localized prostate cancer treatment choice: Systematic review and meta-analysis. CA Cancer J Clin.2015;65(3):239-51. doi: 10.3322/caac.21272. Epub 2015 Mar 12.
  32. Alba AC, Alexander PE, Chang J, MacIsaac J, DeFry S, Guyatt GH.
    High statistical heterogeneity is more frequent in meta-analysis of continuous than binary outcomes. J Clin Epidemiol.2015. pii: S0895-4356(15)00424-2.
  33. Siemieniuk RAC, Taylor GP, Guyatt GH, Lytvyn L, Chang Y, Alexander PE, Lee Y, Agoritsas T, Merglen A, Kirpalani H, Bewley S.
    Authors respond to “Comment from PROMISE team” Re: Antiretroviral therapy in pregnant women living with HIV: a clinical practice guideline 10 October 2017 https://www.bmj.com/content/358/bmj.j3961/rr-0.
  34. Paul E Alexander, Ashley J. Bonner, Arnav Agarwal, Shelly-Anne Li, Abishek Hariharan, Zain Izhar, Neera Bhatnagar, Carolina Alba, Elie Akl, Yutong Fei, Gordon H Guyatt, Joseph Beyene.
    Sensitivity sub-group analysis based on single center versus multi-center trial status when interpreting meta-analyses pooled estimates: the logical way forward. J Clin Epidemiol.2015 Nov 17. pii: S0895-4356(15)00510-7. doi: 10.1016/j.jclinepi.2015.08.027. [Epub ahead of print].
  35. Akl EA, Kahale LA, Agarwal A, Al-Matari N, Ebrahim S, Alexander PE, Briel M, Petersen RB, Busse J, Diab B, Iorio A, Kwong J, Li L, Lopes LC, Mustafa R, Neumann I, Tikkinen KA, Vandvik PO, Zhang Y, Alonso-Coello P, Guyatt G.
    Impact of missing participant data for dichotomous outcomes on pooled effect estimates in systematic reviews: a protocol for a methodological study. Syst Rev. 2014 Nov 26;3(1):137. [Epub ahead of print
  36. Paul E Alexander, Juan P. Brito, Ignacio Neumann, Michael R. Gionfriddo,Lisa Bero, Benjamin Djulbegovic, Rebecca Stoltzfus, Victor M. Montori, Susan L. Norris, Holger J Schünemann, Gordon H Guyatt.
    World Health Organization strong recommendations based on low quality evidence (study quality) are frequent and often inconsistent with GRADE guidance. J Clin Epidemiol.2014 Dec 19. pii: S0895-4356(14)00417-X.
  37. Busse JW, EbrahimS, ConnellG, Coomes EA, Bruno P, Malik K, Torrance D, Ngo T, Kirmayr K, Avrahami D, Riva JJ, Struijs P, Brunarski D, Burnie SJ, LeBlanc F, SteenstraIA, Mahood Q, Thorlund K, Montori VM, Sivarajah V, Alexander P, Jankowski M, Lesniak W, Faulhaber M, Bała MM, Schandelmaier S, Guyatt GH.
    Systematic review and network meta-analysis of interventions for Fibromyalgia: A protocol. Systematic Reviews. 2013, 2: 18. DOI: 10.1186/2046-4053-2-18
  38. Fei Y, Guyatt GH, Alexander PE, El Dib R, Siemieniuk RA, Vandvik PO, Nunnally ME, Gomaa H, Morgan RL, Agarwal A, Zhang Y, Bhatnagar N, Spencer FA.
    Addition of Ezetimibe to statins for patients at high cardiovascular risk: Systematic review of patient-important outcomes. J Eval Clin Pract. 2017 Jan 16. doi: 10.1111/jep.12663.
  39. Neumann I, Santesso N, Akl EA, Rind DM, Vandvik PO, Alonso-Coello P, Agoritsas T, Mustafa RA, Alexander PE, Schünemann H, Guyatt GH.
    A guide for health professionals to interpret and use recommendations in guidelines developed with the GRADE approach. J Clin Epidemiol.2016 Apr;72:45-55. doi: 10.1016/j.jclinepi.2015.11.017. Epub 2016 Jan 6.
  40. Akl EA, Welch V, Pottie K, Eslava-Schmalbach J, Darzi A, Sola I, Katikireddi SV, Singh J, Murad MH, Meerpohl J, Stanev R, Lang E, Matovinovic E, Shea B, Agoritsas T, Alexander PE, Snellman A, Brignardello-Petersen R, Gloss D, Thabane L, Shi C, Stein AT, Sharaf R, Briel M, GuyattG, Schünemann H, Tugwell P.
    GRADE Equity Guidelines 2: Considering health equity in the GRADE guideline development process. J Clin Epidemiol.2017 May 9. pii: S0895-4356(17)30470-5. doi: 10.1016/j.jclinepi.2017.01.017.
  41. Ye, Zhikang MPharm1; Wang, Ying MPharm1; Ge, Long PhD2; Guyatt, Gordon H. MD1,3; Collister, David MD4,5; Alhazzani, Waleed MD1,3; Bagshaw, Sean M. MD6; Belley-Cote, Emilie P. MD1,3; Fang, Fang MD1; Hou, Liangying MSc2; Kolb, Philipp MBA7; Lamontagne, Francois MD8,9; Oczkowski, Simon MD1,3; Pyne, Lonnie MD1,3; Rabbat, Christian MD1,3; Scaum, Matt RN10; Najafabadi, Borna Tadayon MSc1; Tangamornsuksan, Wimonchat PharmD PhD1; Wald, Ron MD11; Wang, Qi MSc1; Walsh, Michael MD1,3,12; Yao, Liang MSc1; Zeng, Linan PhD1,13; Algarni, Abdullah Mohammed MBBS14; Couban, Rachel J. MA, MISt15; Alexander, Paul Elias PhD1; Rochwerg, Bram MD1,3
    Comparing Renal Replacement Therapy Modalities in Critically Ill Patients With Acute Kidney Injury: A Systematic Review and Network Meta-Analysis, Critical Care Explorations: May 2021 – Volume 3 – Issue 5 – p e0399 doi: 10.1097/CCE.0000000000000399.
  42. Cochrane Review/Library, 2011, Foot orthoses for patellofemoral pain in adults Munier Hossain, Paul Alexander, Amanda Burls, Paresh Jobanputra
    Cochrane database of systematic reviews (Online). 01/2011; 1:CD008402.

  43. GIS (Geographic Information Systems) and its role in Canadian Public Health. Canadian Journal of Infectious Diseases. 2003 Jan; (4)
  44. Zhang Y, Tikkinen KA, Agoritsas T, Ayeni OR, Alexander P, Imam M, Yoo D, Tsalatsanis A, Djulbegovic B, Thabane L, Schünemann H, Guyatt GH. BMJ Open.
    2014 Oct 17;4(10):e005536. doi: 10.1136/bmjopen-2014-005536.     Patients’ values and preferences of the expected efficacy of hip arthroscopy for osteoarthritis: a protocol for a multinational structured interview-based study combined with a randomised survey on the optimal amount of information to elicit preferences.
  45. De P, Cox J, Boivin JF, Platt RW, Jolly AM, Alexander PE.
    HIV and HCV discordant injecting partners and their association to drug equipment sharing. Scand J Infect Dis. 2009;41(3):206-14.
  46. Alexander PE,De P,Rave S.
    Is H9N2 avian influenza virus a pandemic potential?     Can J Infect Dis Med Microbiol. 2009 Summer;20(2):e35-6.
  47. Alexander PE, De P.
    HIV-1 and intestinal helminth review update: updating a Cochrane Review and building the case for treatment and has the time come to test and treat? Parasite Immunol.2009;31(6):283-6.
  48. Thomas P, Alexander PE, Ahmed U, et al.
    Vertical transmission risk of SARS-CoV-2 infection in the third trimester: a systematic scoping review [published online ahead of print, 2020 Jul 1].     J Matern Fetal Neonatal Med. 2020;1-8. doi:10.1080/14767058.2020.1786055
  49. Djulbegovic B, Nieuwlaat R, Li SA, Elgayam S, Alexander P, Wiercioch W, Reljic T, Cuker A, Schünemann H, Zhou Q, Guyatt G, Hozo I.
    Structured decision-making drives guidelines panels’ recommendations ‘for’ but not ‘against’ health interventions.     Journal of Clinical Epidemiology. February 2019. In-Press.
  50. The emergence of extensively drug-resistant tuberculosis (TB): TB/HIV coinfection, multidrug-resistant TB and the resulting public health threat from extensively drug-resistant TB, globally and in Canada. P Alexander, P De. Can J Infect Dis Med Microbiol.2007;18(5):289-91.
  51. Manoj J Mammen , Vandana Pai , Shawn D Aaron , Linda Nici , Waleed Alhazzani , and Paul E. Alexander.
    Dual LABA/LAMA Therapy versus LABA or LAMA Monotherapy for COPD: A Systematic Review and Meta-analysis in Support of the American Thoracic Society Clinical Practice Guideline.     Annals of the American Thoracic Society. url: https://www.atsjournals.org/doi/10.1513/AnnalsATS.201912-915OC; online June 21st2020.
  52. Colorectal cancer screening: video-reviewed flexible sigmoidoscopy by nurse endoscopists–a Canadian community-based perspective. Shapero TF, Alexander PE, Hoover J, Burgis E, Schabas R. Canadian Journal of Gastroenterology. 2001 Jul; 15 (7):441-5.
  53. Siemieniuk RAC, Taylor GP, Guyatt GH, Lytvyn L, Chang Y, Alexander PE, Lee Y, Agoritsas T, Merglen A, Kirpalani H, Bewley S. BMJ. Authors respond to “Comment from PROMISE team” Re: Antiretroviral therapy in pregnant women living with HIV: a clinical practice guideline 10 October 2017 https://www.bmj.com/content/358/bmj.j3961/rr-0
  54. Gartman EJ, Mulpuru SS, Mammen MJ, et al. Summary for Clinicians: Clinical Practice Guideline on Pharmacologic Management of Chronic Obstructive Pulmonary Disease [published online ahead of print, 2020 Sep 3]. Ann Am Thorac Soc. 2020;10.1513/AnnalsATS.202007-880CME. doi:10.1513/AnnalsATS.202007-880CME.
  55. Chaudhuri D, Sasaki K, Karkar A, Sharif S, Lewis K, Mammen MJ, Alexander P, Ye Z, Lozano LEC, Munch MW, Perner A, Du B, Mbuagbaw L, Alhazzani W, Pastores SM, Marshall J, Lamontagne F, Annane D, Meduri GU, Rochwerg B. Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis. Intensive Care Med. 2021 Apr 19:1–17. doi: 10.1007/s00134-021-06394-2. Epub ahead of print. PMID: 33876268; PMCID: PMC8054852.